Endocrine Abstracts

A 70-year old man was referred to the endocrinology department for the evaluation of a pituitary macroadenoma which was diagnosed during work-up for a malignant melanoma. Pituitary MRI showed a 20×21×25 mm adenoma with supra-sellar extension and no compression of the optic chiasma. Hormonal work-up revealed central hypogonadism and slight hyperprolactinemia due to stalk compression, while pituitary function was otherwise normal. MRI follow-up was scheduled in six mon...

A 25-year old woman with Hashimoto thyroiditis was referred to the endocrinology department for investigation of a 40 kilogram weight gain, polyuria, polydipsia and secondary amenorrhea. Hormonal work-up showed diabetes insipidus, central hypogonadism, secondary adrenal insufficiency, central hypothyroidism and slight hyperprolactinemia. Pituitary magnetic resonance imaging (MRI) revealed a 15 mm hypothalamic tumor expanding to the infundibulum, associated with pituitary stalk...

Background: Distal symmetric polyneuropathy (DSPN) is one of the most prevalent chronic complications of diabetes and the most common cause in the pathway to diabetic foot ulceration. Screening for DSPN enables early intervention and prevention of complications. The Semmes-Weinstein Monofilament Examination (SWME) is currently the method of choice to screen DSPN, but ideally two neurologic tests should be used. The Michigan Neuropathy Screening Instrument (MNSI), which evaluat...

Background: Hypospadias in boys may be associated with a lack of androgen exposure during the masculinisation programming window. As testosterone has effects on the vasculature, we assessed whether boys with hypospadias show evidence of vascular dysfunction.Methods: Excess foreskin tissue was obtained from boys undergoing hypospadias repair (cases) or circumcision (controls) and small arteries dissected. Vascular contractility was assessed by wire myogra...

Introduction: Insulinomas are almost always located in the pancreas and are usually small. The peak incidence is from the third to fifth decade of life, with females being slightly more frequently affected. The average duration of neuroglycopenic symptoms prior to diagnosis is often prolonged, being more than 5 years in 20% of patients.Case presentation: Female, 52 years old, medical history notable for hypertension, dislipidemia and Graves disease. She ...

Background and aims: Thyroid nodular disease (TND) is a common condition in the general population. Malignant nodules occur in 5% of patients with thyroid nodules. Fine-needle aspiration biopsy (FNAB) is considered to be the most reliable method of differentiating benign and malignant thyroid nodules. The purpose of this study was to assess the accuracy of FNABs performed in our Hospital.Methods: We retrospectively reviewed the medical records of patient...

BackgroundNon-dipping of nocturnal blood pressure is common among people with type 2 diabetes (T2D) and hypertension. Although the mechanism underlying the blunted nighttime response is unclear, insulin resistance is thought to play a role.AimsThis study aims to identify the pattern of nocturnal dipping of blood pressure in patients with T2D from a Portuguese population and its association with micro...

IntroductionDiabetes mellitus (DM) due to cirrhosis is described as hepatogenous diabetes (HD). Despite being frequently described in the literature, it is not recognized as an entity by the ADA/EASD.Case reportWoman, 70 years old, previous history of autoimmune hepatitis with Child-Turcotte-Pugh A cirrhosis (CTP-A) since 2018, arterial hypertension and overweight (BMI 29.1 kg/m2). No personal or f...

IntroductionObesity is a chronic disease that is associated with several comorbidities, decreased quality of life, and increased mortality rate. Bariatric surgery is the most effective therapy for obese patients with class III and class II with metabolic diseases. Its effectiveness is not only related to the weight reduction, but also to the improvement of the metabolic profile. The aim of this study is to characterize the effects of gastroplasty with Ro...

Introduction: The definitive treatment of hyperthyroidism caused by toxic adenoma (TA) and toxic multinodular goiter (TMNG) is ablative therapy with radioactive iodine (RAI) or surgical resection of the hyperfunctioning thyroid nodules. Hypothyroidism after RAI therapy is a common complication.Objectives: To evaluate the prevalence and risk factors of hypothyroidism in patients undergoing RAI for AT and BMNT.Methods: A Multicentre ...